![]() In vivo kinetics of murine hemopoietic stem cells. Dynamic niches in the origination and differentiation of haematopoietic stem cells. High c-Kit expression identifies hematopoietic stem cells with impaired self-renewal and megakaryocytic bias. New evidence supporting megakaryocyte-erythrocyte potential of Fflk2/Flt3 + multipotent hematopoietic progenitors. The bone marrow niche for haematopoietic stem cells. Hematopoietic stem cell niche maintenance during homeostasis and regeneration. An acute negative bystander effect of gamma-irradiated recipients on transplanted hematopoietic stem cells. Homing, cell cycle kinetics and fate of transplanted hematopoietic stem cells. Hematopoietic stem cell transplantation in its 60s: a platform for cellular therapies. From haematopoietic stem cells to complex differentiation landscapes. ![]() Hematopoietic stem cells: concepts, definitions, and the new reality. Therefore, this study uncovers the previously inaccessible kinetics and fate choices of transplanted HSCs in myeloablated recipients at early stage, with implications for clinical applications of HSCs and other stem cells.Įaves, C. ![]() Parallel in vitro and in vivo functional experiments supported the paradigm of robust differentiation without substantial HSC expansion during the first week. Based on our transcriptional classifications, most homed HSCs in bone marrow and spleen became multipotent progenitors and, occasionally, some HSCs gave rise to megakaryocytic–erythroid or myeloid precursors. We then applied them in conjunction with functional assays to track the dynamic changes of immunophenotypically purified HSCs in irradiated recipients within the first week after transplantation. Here, using single-cell RNA sequencing, we first obtained the transcriptome-based classifications of 28 haematopoietic cell types. How transplanted haematopoietic stem cells (HSCs) behave soon after they reside in a preconditioned host has not been studied due to technical limitations.
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